The Hygiene Hypothesis

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We have come a long way in our battle against bacteria, viruses, and parasites etc. We don’t die of infections nearly as frequently anymore due to the effectiveness of antibiotics and other drugs, as well as better cleanliness in all aspects of our life. We know that germs can cause sickness, and so we do what we can to avoid and kill them. 

But are we killing too many of them?  Are we using antibiotics too frequently?   Is it possible to be too clean?   The Hygiene Hypothesis suggests that we are sanitizing our living and working environments to the point where we are increasing the incidence of allergy, asthma, and autoimmune disease.

We have two branches to our immune system that operate differently, and that need to balance each other for optimal health.   The Th1 system of specialized white blood cells attack infected cells in the body thereby preventing an infection from spreading. 

The Th2 system works by developing antibodies to microbes, thereby preventing the infection in the first place.   Infants tend to use almost exclusively the Th2 system to protect themselves, and the Hygiene Hypothosis suggests that infants and young children need exposure to harmless microbes in order to "exercise" the Th1 system and make it strong.  

If that microbe exposure does not happen because the environment has been sanitized with antibacterial products, the Th1 system isn’t developed and the balance between the two systems gets thrown off. The Th2 system then becomes too powerful creating an overreaction or allergic reaction to harmless substances like pollen or animal dander, and the child is then more likely to develop allergies and/or asthma.

Much of the evidence for this is epidemiological.   Researchers found that children that were raised on farms had far less hay fever than children that lived in cities. Young children that had many older siblings had less allergies than those that had few siblings suggesting that the germs that the older kids brought home were protective for the younger ones.  

A study in the Lancet showed that kids from small families that went into daycare before age 1 were less likely to develop allergies than those who began daycare later.

Erika Von Mutuis studied rates of allergy and asthma in East and West Germany and found that the kids that lived in the less clean areas of East Germany had less problems with asthma and allergies than those in West Germany.   The East German kids were more likely to be around other children and animals when they were very young.

There is also evidence that using antibiotics before the age of 2 is linked to allergy and asthma, as antibiotics also kill the “good” bacteria in the gut which is necessary for building a good immune response. Researchers also found that kids that are not vaccinated and are not given antibiotics have fewer allergies than kids that are.

Another group of scientists believe that in the case of autoimmune disease, it is the Th1 response that is dominant, leaving the Th2 system weakened. The concept that too little exposure to infectious agents may contribute to autoimmune disease is very controversial, but there is some evidence supporting the notion.

In an Israeli study, rats in a sterile environment couldn’t develop the immune cells necessary to suppress an autoimmune responses.

So what is the grand message in all of this? We need to be clean, but not too clean. Just like plants can’t be healthy in sterilized dirt, we actually need some contact with the germs, microbes and bacteria that are a part of our environment, so use regular soaps rather than antibacterial soaps and cleaners.

Sometimes it is better to allow a mild illness to run its course rather than to treat it aggressively with drugs and possibly develop allergies later.

Playing in the dirt is good, and having a dog or cat in the house along with the baby and kids is also good.

Taking a probiotic to repopulate the intestinal flora is especially important after finishing a round of antibiotics and may also greatly help the immune system in general.

Related tips:
Food Sensitivities, digestive problems and joint pain

Yeatts et al. A Brief Targeted Review of Susceptibility Factors, Environmental Exposures, Asthma Incidence, and Recommendations for Future Asthma Incidence Research Environmental Health Perspectives Vol. 114, No. 4, April 2006.

Devalapalli et al. Increased Levels of IgE and Autoreactive, Polyreactive IgG in Wild Rodents: Implications for the Hygiene Hypothesis Scandinavian Journal of Immunology Vol 64(2), p. 125, August 2006.

Begany, Timothy. Hygiene Hypothesis gains support in the United States and Europe Online at Respiratory Reviews.com, Vol. 8(1), Jan. 2003.

Alm. J.S. et al. Atopy in children of families with anthroposophic lifestyle Lancet 353:1485, May, 1999.

Braun-Fahrlander, C.H. et al. Prevalence of hay fever and allergic sensitization in farmer’s children and their peers living in the same rural community Journal of Clinical and Experimental Allergy 29:28, January 1999.

Farooqi, IS et al. Early childhood infection and atopic disorder Thorax 53: 927 November 1998.

Kramer, U et al. Age of entry to daycare nursery and allergy in later childhood Lancet 353, Feb. 6, 1999.

Seppa, N. The dark side of immunizations? Science News 152:332, Nov. 22, 1997.

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1 Comment »

  1. Rebecca Cody said,

    December 4, 2011 @ 1:25 pm

    Vreni,

    I’ve been thinking along these lines for a long time. My husband is always using hand sanitizers, but I think they’re mostly a bad idea.

    The book Wheat Belly, by William Davis, MD, also has a lot to say about the origins of asthma, rhumatoid arthritis and other autoimmune diseases, heart disease and cancer, as they relate to the drastic changes in the genetic makeup of wheat in the last 50 years.

    There are so many chemical hazards in the world these days. It’s probably impossible to keep up with it all, but I appreciate your helping with the project.

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